Genetic diversity in the C-terminus of merozoite surface protein 1 among Plasmodium knowlesi isolates from Selangor and Sabah Borneo, Malaysia

NJ Yap; XT Goh; AV Koehler; T William; TW Yeo; I Vythilingam; RB Gasser; YAL Lim

Journal article

Genetic diversity in the C-terminus of merozoite surface protein 1 among Plasmodium knowlesi isolates from Selangor and Sabah Borneo, Malaysia

NJ Yap, XT Goh, AV Koehler, T William, TW Yeo, I Vythilingam, RB Gasser, YAL Lim

Infection Genetics and Evolution | ELSEVIER | Published : 2017

DOI: 10.1016/j.meegid.2017.06.019

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Abstract

Plasmodium knowlesi, a malaria parasite of macaques, has emerged as an important parasite of humans. Despite the significance of P. knowlesi malaria in parts of Southeast Asia, very little is known about the genetic variation in this parasite. Our aim here was to explore sequence variation in a molecule called the 42 kDa merozoite surface protein-1 (MSP-1), which is found on the surface of blood stages of Plasmodium spp. and plays a key role in erythrocyte invasion. Several studies of P. falciparum have reported that the C-terminus (a 42 kDa fragment) of merozoite surface protein-1 (MSP-142; consisting of MSP-119 and MSP-133) is a potential candidate for a malaria vaccine. However, to date, ..

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University of Melbourne Researchers

Anson Koehler Author

Robin B. Gasser Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

Funding from the Australian Research Council (ARC), the National Health and Medical Research Council (NHMRC) of Australia, Melbourne Water Corporation (R.B.G. et al.) and University of Malaya/Ministry of Higher Education High Impact Research (UM.C/625/1/HIR/MOHE/MED/23), University of Malaya (PG056-2013A) (Y.A.L.L. et al.) are gratefully acknowledged. Support from the Endeavour program (ID 4731-2015) is also gratefully acknowledged (NJY).